Methods: This cross-sectional study collected data from a geographically representative random sample of pharmacies. Between December 2022 and November 2023, eligible individuals completed questionnaires covering demographics, lifestyle, medical history, symptoms, treatment, and QoL (CIVIQ-14). Respondents identified their CVD stage using reference photographs.

 

Results: Of 3 417 individuals who were approached, 1 874 met the eligibility criteria and completed the survey. The overall prevalence of CVD was 62.9% (95% confidence interval [CI] 60.6 – 65.3%), with the following C classes: C0s, 17.6%; C1, 25.1%; C2, 10.2%; C3, 31.1%; C4, 11.9%; C5, 3.3%; and C6, 0.9%. CVD prevalence was higher in women (72.6%), older respondents (79.7% in those aged ≥ 80 years), obese individuals (72.3%), those in sedentary occupations (65.9%), and those with family history of CVD (81.3%). In multivariate analysis, a higher odds of CVD was observed in women (odds ratio [OR] 3.54, 95% CI 2.50 – 4.99), older individuals (per decade increase, OR 1.46, 95% CI 1.34 – 1.59), and those with obesity (OR 1.58, 95% CI 1.10 – 2.27), family CVD history (OR 3.93, 95% CI 2.96 – 5.23), and sedentary (OR 1.42, 95% CI 1.04 – 1.95) or standing work (OR 1.99, 95% CI 1.44 – 2.75). Use of compression stockings was 10.6%, 27.4%, and 36.7% in C0s+C1, C2+C3, and C4 – C6 CVD respondents, respectively. Treatment was reported by 38.9%, with prior intervention more common in advanced cases. QoL worsened with increasing disease C class.

 

Conclusion: CVD is highly prevalent in Greece, particularly among females, older adults, and those in sedentary occupations. QoL declines with disease C class, yet treatment remains underutilised, highlighting the need for improved awareness and referral strategies.